Expression and function of G-protein-coupled receptorsin the male reproductive tract
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چکیده
منابع مشابه
Expression and function of G-protein-coupled receptors in the male reproductive tract.
This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), alpha1-adrenoceptors and relaxin receptors in the male reproductive tract. The localization and differential expression of mAChR and alpha1-adrenoceptor subtypes in specific compartments of the efferent ductules, epididymis, vas deferens, seminal vesicle and prostate of various species indicate a ...
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A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
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G-protein-coupled receptors (GPCRs) are widely targeted in drug discovery. As macrophages are key cellular mediators of acute and chronic inflammation, we review here the role of GPCRs in regulating macrophage function, with a focus on contribution to disease pathology and potential therapeutic applications. Within this analysis, we highlight novel GPCRs with a macrophage-restricted expression ...
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ژورنال
عنوان ژورنال: Anais da Academia Brasileira de Ciências
سال: 2009
ISSN: 0001-3765
DOI: 10.1590/s0001-37652009000300002